The most important piece of this answer is that you know the truth. Is your wife leaving you? And if she is leaving you, why is she leaving you.
Is it because you work 6.5 days a week? Is it because when you are home you are messy? Is it because she is in love with someone else? Knowing the answer to this question is very important because without the answer you don't know what you are working with.
Once you do know the answer then you can start taking concrete steps to fixing the issue.
Good luck!!! Mitzi